These are the research directions we focus on in the lab
Understanding human brain development on the single-cell level
We are applying single-cell genomics to human brain tissue samples and cerebral organoids to uncover molecular events that underlie generation, lineage commitment and maturation of specific neural cell types.
Deciphering cell type-specific changes in autism spectrum disorder
We are combining post-mortem tissue and cerebral organoids to study how specific neural cell types change in idiopathic and syndromic autism.
Decoding abnormal neuronal circuits in models of autism
We are using monosynaptic viral tracing combined with single-cell genomics to understand how neuronal circuits are affected in genetic mouse models of autism spectrum disorder. We are also interested in developing novel synaptic tracing methods using barcoded rabies and other neurotropic viruses.
Bioengineering of improved organoid models
We are using 3d bioprinting to develop organoid models that more faithfully match the developing human brain.